Principal Research Scientist II, Phys Chem

Company: Allergan
Location: Lincoln
Posted on: May 2, 2025

Job Description:

Company Description
AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas - immunology, oncology, neuroscience, and eye care - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at. Follow @abbvie on,,,,and.
Job Description
The Structural Biology Group at AbbVie Headquarters in Lake County, Illinois, is seeking a highly motivated scientist with extensive infrastructure experience and people leadership skills to join our Structure-Based Drug Discovery (SBDD) team. The ideal candidate will have a proven track record in SBDD using X-ray crystallography, Cryo-EM, and SAXS, along with a passion for building infrastructure in an industrial pharmaceutical environment. The successful candidate will work with and lead a centralized multidisciplinary Structural Biology team that supports global Discovery Research across AbbVie's portfolio. In addition to driving SBDD, this candidate will play a key role in shaping the group's scientific infrastructure by ensuring technology integration and expansion and developing data management systems to accelerate drug discovery.Key Responsibilities:

• Determine X-ray crystal structures of protein-ligand complexes in high-throughput mode to aid medicinal chemistry design and partner with biologists, molecular modelers, and medicinal chemists to drive SBDD.
• Advance infrastructure initiatives to enhance structural biology workflows, improve data management, and increase cross-functional accessibility to improve efficiency and scientific impact. Design and implement robust, scalable systems for automated data analysis.
• Stay at the forefront of structural biology technologies, bringing in novel capabilities that enhance the scientific infrastructure and enable innovation at AbbVie.
• Provide hands-on and strategic leadership in Cryo-EM and SAXS applications to support diverse drug discovery programs.
• Lead and mentor a team of high-performing scientists in areas of protein crystallization, X-ray crystallography, Cryo-EM, SAXS, and infrastructure development.
• Aid construct design efforts for structural biology efforts.
• Utilize cheminformatics tools and manipulate scripts for use across mixed computing platforms.
• Maintain accurate and timely records of experimental results.
• Communicate results and interpretative analysis through high-impact presentations and reports to internal stakeholders and at external scientific forums. Publish in peer-reviewed journals as appropriate.
• Critically evaluate scientific literature and adopt novel technologies that facilitate structure-based drug discovery at AbbVie.
  Qualifications
  
  • PhD in Chemistry, Biochemistry, Biophysics, or a related field.
  • 12+ years of structural biology experience, with a requirement for industry experience.
  • Deep expertise in protein crystallization and structure determination and analysis using X-ray and Cryo-EM.
  • Familiarity with structure-based drug design strategies.
  • Demonstrated experience in strategizing, executing, and managing scientific infrastructure.
  • Proficiency in programming and scripting skills with the ability to work across various computing environments.
  • Excellent organizational, communication, and leadership skills.
  • Proven ability to work independently as well as part of a highly collaborative, interdisciplinary team.
  • Effective written and verbal communication skills.
  • Ability to manage multiple projects and adapt quickly to evolving priorities in a fast-paced environment.
    Additional Information
    Applicable only to applicants applying to a position in any location with pay disclosure requirements under state orlocal law:
    • The compensation range described below is the range of possible base pay compensation that the Companybelieves ingood faith it will pay for this role at the timeof this posting based on the job grade for this position.Individualcompensation paid within this range will depend on many factors including geographic location, andwemay ultimatelypay more or less than the posted range. This range may be modified in thefuture.
    • We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick),medical/dental/visioninsurance and 401(k) to eligibleemployees.
    • This job is eligible to participate in our short-term incentiveprograms.
    • This job is eligible to participate in our long-term incentiveprogramsNote: No amount of payis considered to bewages or compensation until such amount is earned, vested, anddeterminable.The amount and availability of any bonus,commission, incentive, benefits, or any other form ofcompensation and benefitsthat are allocable to a particular employee remains in the Company's sole andabsolutediscretion unless and until paid andmay be modified at the Company's sole and absolute discretion, consistent withapplicable law.AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.US & Puerto Rico only - to learn more, visitUS & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more:
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Keywords: Allergan, Omaha , Principal Research Scientist II, Phys Chem, Other , Lincoln, Nebraska